abstract：:Acute graft-versus-host disease (aGVHD) is a major complication following transplantation, limiting the success of this therapy. Chitinase 3-like-1 (CHI3L1), a member of the glycosyl hydrolase 18 family, plays a critical role in bacterial infections, allergic disease and a variety of malignancies. Here, we investigate...

journal_title：International immunopharmacology

authors： Li Z,Gu J,Liu J,Zhu Q,Lu H,Lu Y,Rao J,Lu L,Wang X

更新日期：2017-05-01 00:00:00

abstract：:Chlorogenic acid (CGA), one of the most abundant dietary polyphenolic compounds, has been reported to exhibit anti-inflammatory ability. However, the hepatoprotective effects and molecular mechanisms of CGA on concanavalin A (Con A)-induced hepatitis have not been explored. In the present study, we found that pretreat...

journal_title：International immunopharmacology

authors： Yuan Y,Gong X,Zhang L,Jiang R,Yang J,Wang B,Wan J

更新日期：2017-03-01 00:00:00

abstract：:Hypoxic tumor microenvironment makes cancer cells to be therapy-resistant and hypoxia-inducing factors (HIFs) play a central role in hypoxic adaptation. Especially, renal cell carcinoma (RCC) is often associated with von Hippel-Lindau (VHL) gene mutations, leading to up-regulation of HIFs. However, from a different po...

journal_title：International immunopharmacology

authors： Minami T,Matsumura N,Sugimoto K,Shimizu N,De Velasco M,Nozawa M,Yoshimura K,Harashima N,Harada M,Uemura H

更新日期：2017-03-01 00:00:00

abstract：:A series of nitro substituted benzamide derivatives were synthesized and evaluated for their potential anti-inflammatory activities in vitro. Firstly, all compounds (1-6) were screened for their inhibitory capacity on LPS induced nitric oxide (NO) production in RAW264.7 macrophages. Compounds 5 and 6 demonstrated sign...

journal_title：International immunopharmacology

authors： Tumer TB,Onder FC,Ipek H,Gungor T,Savranoglu S,Tok TT,Celik A,Ay M

更新日期：2017-02-01 00:00:00

abstract：:Bariatric surgeries, including Roux-en-Y gastric bypass (RYGB) are currently the best treatment for obesity and obesity-related comorbidities, such as type 2 diabetes. However, the underlying mechanism of bariatric surgeries is not entirely understood. Further investigations are needed to improve the success rate and ...

journal_title：International immunopharmacology

authors： Dai X,Zhao W,Zhan J,Zeng S,Ran D,Zhang H,Song Z,Song KH,Wu L

更新日期：2017-02-01 00:00:00

abstract：:Berberine (BBR), one of the main bioactive compounds in Rhizoma coptidis, has multiple pharmacological activities. It has been reported that 8-cetylberberine (8-BBR-C16) has increased anti-microbial property in vivo and a higher bioavailability in hamsters. Therefore, in the present study, we used apolipoprotein E-def...

journal_title：International immunopharmacology

authors： Feng M,Zou Z,Zhou X,Hu Y,Ma H,Xiao Y,Li X,Ye X

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Astragaloside IV (AS-IV), the major active triterpenoid in Radix Astragali, has shown anti-tumorigenic properties in certain cancers; however, its role in breast cancer remains unclear. The present study investigated the effects of AS-IV on breast cancer in vitro and in vivo and examined the underlying mecha...

journal_title：International immunopharmacology

authors： Jiang K,Lu Q,Li Q,Ji Y,Chen W,Xue X

更新日期：2017-01-01 00:00:00

abstract：:Calea uniflora Less. (family Asteraceae), also named "arnica" and "erva-de-lagarto", is a native plant to the South and Southeast of Brazil. This species was used to treat rheumatism, respiratory diseases, and digestive problems in Brazilian folk medicine. In vitro studies have shown the important biological effects o...

journal_title：International immunopharmacology

authors： da Rosa JS,de Mello SV,Vicente G,Moon YJ,Daltoé FP,Lima TC,de Jesus Souza R,Biavatti MW,Fröde TS

更新日期：2017-01-01 00:00:00

abstract：:The changes in molecular structure and anti-inflammatory action of a gamma-irradiated quercetin were examined. Quercetin was gamma-irradiated at doses of 0, 15, 30, 50, 100 and 150kGy, which induced new radiolytic peaks (the highest radiolytic peak at a dose of 30kGy). Treatment of intact- and gamma-irradiated quercet...

journal_title：International immunopharmacology

authors： Byun EB,Jang BS,Kim HM,Yang MS,Sung NY,Byun EH

更新日期：2017-01-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide. The PD-1/PD-L1 interaction plays important roles in cancer immunology, and expression of PD-L1 has been discovered in NSCLC tumor cells. Since follicular helper T (Tfh) cells have characteristic high PD-1 expression,...

journal_title：International immunopharmacology

authors： Ma QY,Huang DY,Zhang HJ,Chen J,Miller W,Chen XF

更新日期：2016-12-01 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) is associated with an immune dysregulation usually mediated by T lymphocytes. Recently, IL-17-producing T cells including Th17 and Tc17 cells have been implicated in immune-related diseases. However, their roles in aGVHD remain uncertain. In the study, we analyzed IL-17-producin...

journal_title：International immunopharmacology

authors： Wang L,Zhao P,Song L,Yan F,Shi C,Li Y,Han M,Lan K

更新日期：2016-12-01 00:00:00

abstract：:The most effective treatment for HBV-related hepatocellular carcinoma (HCC) is surgical removal of the tumor in early stage patients. But many such patients will develop recurrent tumor within the first 24months, which is the major cause of death. To enable the prevention and earlier detection of recurrent HCC, we inv...

journal_title：International immunopharmacology

authors： Song B,Zhen S,Meng F

更新日期：2016-12-01 00:00:00

abstract：:Many edible mushrooms have become attractive as "health foods" and as source materials for immunomodulators. To increase our insight in the immune-modulatory properties of a polysaccharide of the oyster mushroom Pleurotus citrinopileatus, PCPS, we analyzed its effects on the function of human dendritic cells (DCs). We...

journal_title：International immunopharmacology

authors： Minato KI,Laan LC,Ohara A,van Die I

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To explore the relationship between LOX-1 and TLR4 in Aspergillus fumigatus (A. fumigatus) keratitis. To determine LOX-1 and TLR4 can affect each other and regulate inflammation through regulation of the generation of reactive oxygen species (ROS) in A. fumigatus keratitis. METHODS:The cornea and abdominal cav...

journal_title：International immunopharmacology

authors： Gao X,Zhao G,Li C,Lin J,Jiang N,Wang Q,Hu L,Xu Q,Peng X,He K,Zhu G

更新日期：2016-11-01 00:00:00

abstract：:Flavonoids, particularly those derived from plants, harbor biological effects such as anti-inflammation and the inhibition of cancer progression. In the present study, we investigated the effects of 10 kinds of flavonoids isolated from Nepalese propolis on the LPS signaling pathway in order to clarify their anti-infla...

journal_title：International immunopharmacology

authors： Funakoshi-Tago M,Ohsawa K,Ishikawa T,Nakamura F,Ueda F,Narukawa Y,Kiuchi F,Tamura H,Tago K,Kasahara T

更新日期：2016-11-01 00:00:00

abstract：:Azithromycin (AZM) is a macrolide antibiotic that exhibits anti-inflammatory activity aside from its antimicrobial effect, a feature that may ameliorate certain inflammatory disorders and prevent graft-versus-host disease in patients receiving stem cell transplantation. In the present study, we investigated the abilit...

journal_title：International immunopharmacology

authors： Lin SJ,Kuo ML,Hsiao HS,Lee PT

更新日期：2016-11-01 00:00:00

abstract：:Emerging evidences indicated that NLRP3 inflammasome initiates inflammatory response involved in cardiovascular disease. Nicotinic acid (NA) has been known to possess potential anti-inflammatory property. The aim of this study was to investigate the effect of NA on the activation of NLRP3 inflammasome and the underlyi...

journal_title：International immunopharmacology

authors： Li Y,Yang G,Yang X,Wang W,Zhang J,He Y,Zhang W,Jing T,Lin R

更新日期：2016-11-01 00:00:00

abstract：:Transmembrane protein 16A (TMEM16A), a channel underlying the calcium-activated chloride channel (CaCC) currents, has been shown to be a key regulator of mucus overproduction in airway epithelial cells. However, the precise molecular mechanism involved in the TMEM16A-mediated mucus secretion remains unclear. In the pr...

journal_title：International immunopharmacology

authors： Qin Y,Jiang Y,Sheikh AS,Shen S,Liu J,Jiang D

更新日期：2016-11-01 00:00:00

abstract：:Hepatitis B is one of the leading liver diseases and remains a major global health problem. Currently available vaccines provide protection but often results in weaker/minimal mucosal immunity. Thus the present study is devoted to the development and in-vivo exploration of the colonically delivered biomimetic nanopart...

journal_title：International immunopharmacology

authors： Sahu KK,Pandey RS

更新日期：2016-10-01 00:00:00

abstract：:Dopamine (DA), an important neurotransmitter, has been reported to play a negative role in tumor progression. DA acts its role via dopamine receptors (DRs), which can be divided into five receptor subtypes (D1R-D5R). Among these receptor subtypes, D2R has been found to inhibit IGF-I-induced gastric cancer cell growth....

journal_title：International immunopharmacology

authors： Huang H,Wu K,Ma J,Du Y,Cao C,Nie Y

更新日期：2016-10-01 00:00:00

abstract：:The RNA-binding protein tristetraprolin (TTP) is an adenine/uridine (AU)-rich elements (AREs)-binding protein that can induce the decay of AREs containing mRNAs. In this study, we demonstrated that TTP is significantly down-regulated in human glioma tissue samples and cell lines. It is also associated with diminished ...

journal_title：International immunopharmacology

authors： Zeng B,Zhu D,Su Z,Li Z,Yu Z

更新日期：2016-10-01 00:00:00

abstract：:Airway remodeling includes lung structural changes that have a role in the irreversibility of pulmonary dysfunction shown in chronic bronchial asthmatics. The current experiment investigated the effect of the mitochondrial antioxidant, tiron in comparison with dexamethasone (DEXA) on airway remodeling in chronic asthm...

journal_title：International immunopharmacology

authors： El-Sherbeeny NA,Hassan ZA,Ateyya H

更新日期：2016-10-01 00:00:00

abstract：:It is generally accepted that the appropriate boost of early immune response will control viral replications and limit the immune-mediated pathology in viral hepatitis. However, poor immunity results in viral persistence, chronic inflammation and finally liver cirrhosis and carcinoma. As a peripheral non-lymphoid orga...

journal_title：International immunopharmacology

authors： Liang Y,Kwota Z,Sun J

更新日期：2016-10-01 00:00:00

abstract：:We have used a high throughput small molecule screen, using a fission yeast-based assay, to identify novel phosphodiesterase 7 (PDE7) inhibitors. One of the most effective hit compounds was BC12, a barbituric acid-based molecule that exhibits unusually potent immunosuppressive and immunomodulatory actions on T lymphoc...

journal_title：International immunopharmacology

authors： Xu C,Wyman AR,Alaamery MA,Argueta SA,Ivey FD,Meyers JA,Lerner A,Burdo TH,Connolly T,Hoffman CS,Chiles TC

更新日期：2016-09-01 00:00:00

abstract：:In this study, we investigated the preventive effects of curcumin using dextran sulfate sodium (DSS)-induced colitis and the potential role of curcumin in regulation of anti-inflammation through S-nitrosylation. After curcumin treatment for 6days, the body weight and disease activity index of DSS-induced mice was alle...

journal_title：International immunopharmacology

authors： Kao NJ,Hu JY,Wu CS,Kong ZL

更新日期：2016-09-01 00:00:00

abstract：:Temporomandibular joint (TMJ) disorders show inflammatory components, heavily impacting on quality of life. Abelmoschus esculentus is largely cultivated in Northeastern Brazil for medicinal purposes, having it shown anti-inflammatory activity. We evaluated A. esculentus lectin (AEL) efficacy in reducing zymosan-induce...

journal_title：International immunopharmacology

authors： Freitas RS,do Val DR,Fernandes ME,Gomes FI,de Lacerda JT,SantiGadelha T,de Almeida Gadelha CA,de Paulo Teixeira Pinto V,Cristino-Filho G,Pereira KM,de Castro Brito GA,Bezerra MM,Chaves HV

更新日期：2016-09-01 00:00:00

abstract：:The effective antitumor immune responses are dependent on coordinate interaction of various effector cells. Thus, the combination of adoptive immunotherapy and target gene therapy is capable of efficiently generating a productive antitumor immune response. We investigated whether combination of cytokine-induced killer...

journal_title：International immunopharmacology

authors： Ye JF,Lin YQ,Yu XH,Liu MY,Li Y

更新日期：2016-09-01 00:00:00

abstract：:Mast cells play a critical role in allergic diseases. Therefore, development of new therapeutic agents that suppresses the activation of mast cells may help prevent or treat allergic diseases. Here, we investigated the anti-allergic effects of 4-chloro-cinnamaldehyde and 4-trifluoro-cinnamaldehyde in RBL-2H3 cells. β-...

journal_title：International immunopharmacology

authors： Ahn S,Kim E,Lee K,Lee DC

更新日期：2016-09-01 00:00:00

abstract：:Acute lung injury (ALI), induced by intestinal ischemia reperfusion (II/R) injury, is characterized by pulmonary edema and inflammation. Aquaporin 4 (AQP4), has been pointed out recently involving in edema development. Previous studies have shown that p38 mitogen activated protein kinase (MAPK) activation resulted in ...

journal_title：International immunopharmacology

authors： Xiong LL,Tan Y,Ma HY,Dai P,Qin YX,Yang RA,Xu YY,Deng Z,Zhao W,Xia QJ,Wang TH,Zhang YH

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:To explore the role of autophagy on macrophage-mediated phagocytosis and intracellular killing of Pseudomonas aeruginosa (PA), a common extracellular bacterium which often causes various opportunistic infections. METHODS:Macrophages were infected with PA or stimulated with zymosan bioparticles. Autophagy wa...

journal_title：International immunopharmacology

authors： Wu Y,Li D,Wang Y,Chen K,Yang K,Huang X,Zhang Y,Wu M

更新日期：2016-09-01 00:00:00

abstract：:Severe acute pancreatitis (SAP) is a severe clinical condition with significant morbidity and mortality. Multiple organs dysfunction (MOD) is the leading cause of SAP-related death. The over-release of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α is the underlying mechanism of MOD; however, there is no ef...

journal_title：International immunopharmacology

authors： Cen Y,Liu C,Li X,Yan Z,Kuang M,Su Y,Pan X,Qin R,Liu X,Zheng J,Zhou H

更新日期：2016-09-01 00:00:00

abstract：:We can now declare that the clinical goal of immune intervention as a therapeutic strategy for neoplastic, infectious, autoimmune and inflammatory diseases, has been achieved and in many instances obtained regulatory approval. Although, interest in and optimism for this approach has fluctuated, in the last 20years, im...

journal_title：International immunopharmacology

authors： Talmadge JE

更新日期：2016-08-01 00:00:00

abstract：:The proteasome influences cellular homeostasis through the degradation of regulatory proteins, many of which are also involved in disease pathogenesis. In particular, numerous regulatory proteins associated with tumor growth, such as cyclins, cyclin-dependent kinase inhibitors, tumor suppressors, and NF-κB inhibitors ...

journal_title：International immunopharmacology

authors： Momose I,Kawada M

更新日期：2016-08-01 00:00:00

abstract：:Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. Clinical trial studies in cancer patients have s...

journal_title：International immunopharmacology

authors： Zhao D,Plotnikoff N,Griffin N,Song T,Shan F

更新日期：2016-08-01 00:00:00

abstract：:This study was aimed to investigate the anti-tumor and immunomodulatory activities of an exopolysaccharide (EPS) from Rhizopus nigricans. Our results showed EPS could significantly inhibit the tumor growth and increase the immune organs index of CT26 tumor-bearing mice. EPS treatment increased the productions of inter...

journal_title：International immunopharmacology

authors： Zhu L,Cao J,Chen G,Xu Y,Lu J,Fang F,Chen K

更新日期：2016-07-01 00:00:00

abstract：:Ulcerative colitis is a chronic nonspecific inflammatory disease of unknown cause. The aim of this study was to evaluate the anti-inflammatory effect of tauroursodeoxycholate in 2, 4, 6-trinitrobenzenesulfonic acid-induced experimental colitis in mice. After the induction of colitis for 24h, the mice were administrate...

journal_title：International immunopharmacology

authors： Yang Y,He J,Suo Y,Zheng Z,Wang J,Lv L,Huo C,Wang Z,Li J,Sun W,Zhang Y

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Immunomodulation by indoleamine 2,3-dioxygenase (IDO) has been documented in many studies yet its underlying mechanisms remain undefined, especially in solid organ transplantation. Recent research demonstrated that the active expression of IDO in dendritic cells (DCs) regulates immune reaction. This study as...

journal_title：International immunopharmacology

authors： Li C,Liu T,Zhao N,Zhu L,Wang P,Dai X

更新日期：2016-07-01 00:00:00

abstract：:Total glucosides of paeony (TGP) is a bioactive compound extracted from paeony roots and has been widely used to ameliorate inflammation in several autoimmune and inflammatory diseases. However, the anti-inflammatory effect of TGP on oral lichen planus (OLP), a chronic inflammatory oral condition characterized by T-ce...

journal_title：International immunopharmacology

authors： Wang Y,Zhang H,Du G,Wang Y,Cao T,Luo Q,Chen J,Chen F,Tang G

更新日期：2016-07-01 00:00:00

abstract：:CXCR4 is a member of chemokine receptors and plays a vital role in numerous diseases and cancer processes, which makes the CXCR4/CXCL12 chemotactic axis a potential therapeutic target. In this study, we used lentiviral vectors as a novel technology to produce a monoclonal antibody against CXCR4. Lentivirus vector pLV-...

journal_title：International immunopharmacology

authors： Li X,Kuang Y,Huang X,Zou L,Huang L,Yang T,Li W,Yang Y

更新日期：2016-07-01 00:00:00

abstract：:Visfatin plays an important role in inflammatory and metabolic conditions. In this study, the effects of septic stress on the serum, white-adipose-tissue (WAT), and liver visfatin levels of male and female rats were examined. Both gonadally intact (sham) and ovariectomized (OVX) female rats were used in order to evalu...

journal_title：International immunopharmacology

authors： Iwasa T,Matsuzaki T,Matsui S,Tungalagsuvd A,Munkhzaya M,Takiguchi E,Kawakita T,Kuwahara A,Yasui T,Irahara M

更新日期：2016-06-01 00:00:00